Thyroid hormone receptors and ligands, tissue distribution and sexual behavior
نویسندگان
چکیده
منابع مشابه
Tissue-specific thyroid hormone regulation of gene transcripts encoding iodothyronine deiodinases and thyroid hormone receptors in striped parrotfish (Scarus iseri).
In fish as in other vertebrates, the diverse functions of thyroid hormones are mediated at the peripheral tissue level through iodothyronine deiodinase (dio) enzymes and thyroid hormone receptor (tr) proteins. In this study, we examined thyroid hormone regulation of mRNAs encoding the three deiodinases dio1, dio2 and dio3 - as well as three thyroid hormone receptors trαA, trαB and trβ - in init...
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Members of the nuclear steroid hormone superfamily mediate essential physiological functions. Steroid hormone receptors (SHR) act directly on DNA, regulate the synthesis of their target genes and are usually activated by ligand binding. Both endogenous and exogenous compounds and their metabolites may act as activators of SHR and disruptors of endocrine, cellular and lipid homeostasis. The endo...
متن کاملA Link Between Maternal Thyroid Hormone and Sexual Orientation?
The search for the cause of gender nonconformity and homosexuality has been extensive. Researchers have proposed a variety of different causes, from early childhood experiences to birth order to hormonal influences,1-3 but have yet to pinpoint a reliable explanation of our sexual orientation. Prior research into biological influences of sexual orientation has focused on adult hormone levels,3 a...
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In recent years a large amount of data has been gathered on the biology of thyroid hormone receptors. The receptor proteins have been analyzed from the physiological and structural points of view. Most of the information has been summarized in several recent excellent reviews (1–6). The thyroid hormone receptors (TR) are ligand-modulated transcription factors which are members of a large superf...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2018
ISSN: 0303-7207
DOI: 10.1016/j.mce.2017.11.006